This study investigated the potential of Persea americana stem bark for the treatment of inflammation and oxidation in mice. Oxidative stress occurs in the body when there is serious imbalance between the generation of free radicals and the antioxidant defense system, inflammation is a natural defense mechanism against pathogens and it is associated with many pathogenic diseases such as microbial and viral infections, exposure to allergens, radiation and toxic chemicals, autoimmune and chronic diseases, obesity, consumption of alcohol, tobacco use, and a high-calorie diet. Plants offer significant potentials for development of new anti-inflammatory therapies and treatment of diseases associated with inflammation and Oxidation. Stem bark of Persea ameriacna was extracted using EtOH/H2O (80:20 v/v), the extract obtained was subjected to maceration using 3 different solvents, hexane fraction (PAHF), Ethyl-acetate fraction (PAEF) and methanol fraction (PAMF). The methanol fraction came out with the highest yield and was used for the animal study, 30 male mice was divided into 3 different groups, LPS was introduced in one of the groups, PAMF was later administered to the same group, The experiment shows that the extract was able to demonstrate significant reduction in inflammation and also ameliorate oxidation in mice. In conclusion the methanolic fraction of Persea americana stem bark might contain beneficial phytochemicals that can be explored as potential anti-inflammatory and oxidative therapy.
| Published in | International Journal of Biomedical Science and Engineering (Volume 12, Issue 1) |
| DOI | 10.11648/j.ijbse.20241201.11 |
| Page(s) | 1-9 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
P. americana, Methanolic Extract, LPS, Anti-inflammation
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APA Style
Oluwatoyin, B., Olasunkanmi, A. M., Ayokanmi, O. (2024). Therapeutic Potential of Persea americana Stem Bark in Lipopolysaccharide (LPS) Induced Hepatic Inflammation and Oxidative Stress in Mice. International Journal of Biomedical Science and Engineering, 12(1), 1-9. https://doi.org/10.11648/j.ijbse.20241201.11
ACS Style
Oluwatoyin, B.; Olasunkanmi, A. M.; Ayokanmi, O. Therapeutic Potential of Persea americana Stem Bark in Lipopolysaccharide (LPS) Induced Hepatic Inflammation and Oxidative Stress in Mice. Int. J. Biomed. Sci. Eng. 2024, 12(1), 1-9. doi: 10.11648/j.ijbse.20241201.11
AMA Style
Oluwatoyin B, Olasunkanmi AM, Ayokanmi O. Therapeutic Potential of Persea americana Stem Bark in Lipopolysaccharide (LPS) Induced Hepatic Inflammation and Oxidative Stress in Mice. Int J Biomed Sci Eng. 2024;12(1):1-9. doi: 10.11648/j.ijbse.20241201.11
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Download@article{10.11648/j.ijbse.20241201.11,
author = {Babatunde Oluwatoyin and Amuda Mutiu Olasunkanmi and Ore Ayokanmi},
title = {Therapeutic Potential of Persea americana Stem Bark in Lipopolysaccharide (LPS) Induced Hepatic Inflammation and Oxidative Stress in Mice
},
journal = {International Journal of Biomedical Science and Engineering},
volume = {12},
number = {1},
pages = {1-9},
doi = {10.11648/j.ijbse.20241201.11},
url = {https://doi.org/10.11648/j.ijbse.20241201.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20241201.11},
abstract = {This study investigated the potential of Persea americana stem bark for the treatment of inflammation and oxidation in mice. Oxidative stress occurs in the body when there is serious imbalance between the generation of free radicals and the antioxidant defense system, inflammation is a natural defense mechanism against pathogens and it is associated with many pathogenic diseases such as microbial and viral infections, exposure to allergens, radiation and toxic chemicals, autoimmune and chronic diseases, obesity, consumption of alcohol, tobacco use, and a high-calorie diet. Plants offer significant potentials for development of new anti-inflammatory therapies and treatment of diseases associated with inflammation and Oxidation. Stem bark of Persea ameriacna was extracted using EtOH/H2O (80:20 v/v), the extract obtained was subjected to maceration using 3 different solvents, hexane fraction (PAHF), Ethyl-acetate fraction (PAEF) and methanol fraction (PAMF). The methanol fraction came out with the highest yield and was used for the animal study, 30 male mice was divided into 3 different groups, LPS was introduced in one of the groups, PAMF was later administered to the same group, The experiment shows that the extract was able to demonstrate significant reduction in inflammation and also ameliorate oxidation in mice. In conclusion the methanolic fraction of Persea americana stem bark might contain beneficial phytochemicals that can be explored as potential anti-inflammatory and oxidative therapy.
},
year = {2024}
}
TY - JOUR T1 - Therapeutic Potential of Persea americana Stem Bark in Lipopolysaccharide (LPS) Induced Hepatic Inflammation and Oxidative Stress in Mice AU - Babatunde Oluwatoyin AU - Amuda Mutiu Olasunkanmi AU - Ore Ayokanmi Y1 - 2024/04/02 PY - 2024 N1 - https://doi.org/10.11648/j.ijbse.20241201.11 DO - 10.11648/j.ijbse.20241201.11 T2 - International Journal of Biomedical Science and Engineering JF - International Journal of Biomedical Science and Engineering JO - International Journal of Biomedical Science and Engineering SP - 1 EP - 9 PB - Science Publishing Group SN - 2376-7235 UR - https://doi.org/10.11648/j.ijbse.20241201.11 AB - This study investigated the potential of Persea americana stem bark for the treatment of inflammation and oxidation in mice. Oxidative stress occurs in the body when there is serious imbalance between the generation of free radicals and the antioxidant defense system, inflammation is a natural defense mechanism against pathogens and it is associated with many pathogenic diseases such as microbial and viral infections, exposure to allergens, radiation and toxic chemicals, autoimmune and chronic diseases, obesity, consumption of alcohol, tobacco use, and a high-calorie diet. Plants offer significant potentials for development of new anti-inflammatory therapies and treatment of diseases associated with inflammation and Oxidation. Stem bark of Persea ameriacna was extracted using EtOH/H2O (80:20 v/v), the extract obtained was subjected to maceration using 3 different solvents, hexane fraction (PAHF), Ethyl-acetate fraction (PAEF) and methanol fraction (PAMF). The methanol fraction came out with the highest yield and was used for the animal study, 30 male mice was divided into 3 different groups, LPS was introduced in one of the groups, PAMF was later administered to the same group, The experiment shows that the extract was able to demonstrate significant reduction in inflammation and also ameliorate oxidation in mice. In conclusion the methanolic fraction of Persea americana stem bark might contain beneficial phytochemicals that can be explored as potential anti-inflammatory and oxidative therapy. VL - 12 IS - 1 ER -
Department of Physical Sciences, Ajayi Crowther University, Oyo, Nigeria
Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
